The goal of the Antibiotic Resistance Working Group is to better understand the rapid spread of antimicrobial resistance across the world and ultimately to stave off the high mortality and morbidity resulting from infections with resistant bacteria. develop basic infrastructure to evaluate antimicrobial resistance across two disparate healthcare systems in different parts of the world and to understand how healthcare providers make decisions around antibiotic prescribing.
About the Project
The Antibiotic Resistance Working Group aims to create a global collaboration to coordinate responses to antimicrobial resistance (AMR) across academic, political, pharmaceutical and medical institutions. This collaborative effort will enable 1) forecasting, detection and prevention of the emergence of AMR in communities, 2) rapid identification of AMR, supporting better clinical decisions about the use of antimicrobials or alternative and potentially novel approaches to treat patients, thereby preserving the long term efficacy of existing antibiotics, and 3) a better understanding of how people make decisions around antibiotic prescription and non-antibiotic interventions to treat infectious diseases. Through global efforts to prevent the spread of AMR, hundreds of thousands of lives will be saved.
Our group’s project will use a collaboration between Northwestern University, USA, and Aga Khan University, Pakistan, as a case study for this project. We aim to have the following outcomes: 1) development of infrastructure to evaluate AMR across two disparate healthcare systems, and 2) understanding of how health-care providers make decisions around antibiotic prescribing. The collaborative infrastructure we develop will enable us to identify best practices for collecting standardized patient-level, microbiologic and bacterial genomic data. Analyzing these data will provide a framework for global collaborative efforts to identify, investigate and prevent the spread of antimicrobial resistance. By further understanding the decision-making process, and the emotional and economic drivers behind this process, we will design and implement behavioral interventions to help providers change in a meaningful and productive way across different clinical settings.
Mehreen Arshad (Pediatrics, Feinberg School of Medicine)*
Katie Amato (Anthropology, Weinberg College of Arts and Sciences)
Jim Davis (Argonne Lab)
Charlesnika Evans (Preventive Medicine, Northwestern Memorial Hospital)
Erica Hartmann (Civil and Environmental Engineering, McCormick School of Engineering)*
Faisal Mahmood (Adult Infectious Disease, Aga Khan University, Pakistan)
Leena Mithal (Feinberg School of Medicine)
Larry K. Kociolek (Feinberg School of Medicine)
Egon Ozer (Feinberg School of Medicine)
Sameer J. Patel (Feinberg School of Medicine)
Noelle Samia (Statistics, Weinberg College of Arts and Sciences)
Patrick Seed (Feinberg School of Medicine)
*indicates group leaders